Asymmetric Reactions Using Non-natural Chiral Auxiliaries.
نویسندگان
چکیده
منابع مشابه
Chiral Auxiliaries in Asymmetric Synthesis
Background The use of chiral auxiliaries in the synthesis of enantiomerically pure compounds has found wide application for a variety of reactions over the last three decades. Despite the extensive developments in this area by many academic and industrial research groups, new auxiliary controlled reactions continue to evolve frequently [1]. First objectives in this area have been to develop chi...
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Helicenes are unique helical chromophores possessing advanced and well-controlled spectral and chemical properties owing to their diverse functionalization and defined structures. Specific modification of these molecules by introducing aromatic rings of differing nature and different functional groups results in special chiroptical properties, making them effective chiral auxiliaries and supram...
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[reaction: see text] Highly diastereoselective acetate aldol additions using chlorotitanium enolates of mesityl-substituted N-acetyloxazolidinethione and N-acetylthiazolidinethione auxiliaries are reported. These additions proceed in high yields and diastereoselectivities (93:7 to 98:2) for aliphatic, aromatic, and ,-unsaturated aldehydes. Double diastereoselective acetate aldol additions are a...
متن کاملTitanium enolates of thiazolidinethione chiral auxiliaries: versatile tools for asymmetric aldol additions.
[formula: see text] Asymmetric aldol additions using chlorotitanium enolates of thiazolidinethione propionates proceed with high diastereoselectivity for the "Evans" or "non-Evans" syn product depending on the nature and amount of the base used. With (-)-sparteine as the base, selectivities of 97:3 to > 99:1 were obtained for the Evans syn products with 2 equivalents of base and for the non-Eva...
متن کاملNon-cross-linked polystyrene-supported 2-imidazolidinone chiral auxiliary: synthesis and application in asymmetric alkylation reactions
Asymmetric alkylation reactions using non-cross-linked polystyrene (NCPS)-supported 2-imidazolidinone chiral auxiliaries were successfully investigated with excellent diastereocontrol (>99% de). The recovery and the recycling of this soluble polymer-supported chiral auxiliary were achieved in order to produce highly optical pure carboxylic acids.
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ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 1998
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.56.386